Scientists are alarmed by the use of fungicides. In a tribune published in Liberation Monday, April 16, 2018 a group of researchers, oncologists, doctors and toxicologists of CNRS, Inserm and Inra ] call for the suspension of the use of the SDHI, succinate dehydrogenase inhibitors. These are used in large proportion in the French agriculture and on lawns, especially those of golf courses, to kill fungi and molds. SDHIs prevent the development of fungi by blocking their respiration, which is provided by succinate dehydrogenase (SDH). SDHI fungicides are used extensively on many crops. For example, 70% of soft wheat surfaces and 80% of winter barley were treated with this product in 2014. The researchers explain that after spraying on crops, the fungicide ends up in the soil. , in water and in animal and human nutrition. But this passage in the human food chain can seriously damage their health .
" Universal cellular respiration and SDH enzyme function in all living species. How not to feel concerned by the presence of the SDHI in our plates through the contamination of food? How could such pesticides be placed on the market with the assurance of having no impact on human health, but also on the entire ecosystem? ", s' ask the authors of the platform.
Thus, the cells of all living beings breathe, from fungi through micro-organisms and of course man. " Our research on the SDH enzyme has revealed a very particular mechanism of cellular disruption: the blocking of this enzyme leads to the accumulation of a small molecule, succinate. This will lead to a long-term change in the structure of our DNA: these are epigenetic modifications phenomena.These epigenetic abnormalities linked to the blocking of SDH will deregulate thousands of genes, explaining the occurrence of tumors and cancers, without causing mutations in genes, as is often the case with carcinogens, and these modifications, unlike mutations, are not detected or tested during toxicity tests conducted before the pesticides are placed on the market  ", explain the scientists, because the long-term toxicity of SDHI fungicide to humans has never been seriously studied. However, The effects of SDH enzyme " can lead to cell death by causing severe encephalopathies, or uncontrolled cell proliferation, and leading to cancer ". In addition, Pierre Rustin, geneticist and research director at the CNRS-Inserm, ensures, in the gallery, that these fungicides " block well the human SDH, we tested it in the laboratory. However, we know that it is extremely dangerous to block this enzyme . "
Suspension of authorization
The fungicide was set up by major industrialists among which the now famous ] Monsanto and Bayer. The use of the SDHI was authorized in 2009 as a substitute for other pesticides previously manufactured and since abandoned because of their dangerousness, their reduced effectiveness and / or the appearance of resistance. " It is now very difficult to access the information that gave rise to the marketing authorizations for these molecules, but, to our knowledge, only a few tests on the toxicity at the human were made by the firms themselves ", say the authors of the forum.
ANSES, the National Agency for Food Safety, the Environment and Labor, and INRA, the National Institute for Agricultural Research, have both noticed that fungi and mold begin to develop resistance to SDHI. In addition to being potentially dangerous for humans, this product would have become equally inefficient.
The collective, author of the tribune, calls for " to suspend the use (of the SDHI) as long as an estimate of the dangers and the risks will not have been carried out by public bodies independent of the industrialists distributing these compounds and agencies that previously gave the marketing authorizations of the SDHI ". The association Générations Futures for its part, asked ANSES, in a communiqué the " urgent review of the evaluation of these SDHI fungicides and that an immediate suspension of their authorizations ".